So all credit to @Niche fan for suggesting this! But they never explained how it would work in game, so I'm suggesting how it will work! So, I'm doing this because I noticed it was in the second community voting of the top 20 most voted. So, here we go!
List of all heterochromia I have seen in cats in pictures:
Yellow-Blue
Blue-Orange
Blue-Green
Green-Blue
Brown-Blue
Of course we can make other color combinations, but yup.
So I'll use Brown-Blue as my example.
The left side